Identification of mammary carcinogens in rodent bioassays
نویسندگان
چکیده
منابع مشابه
Predictions for the outcome of rodent carcinogenicity bioassays: identification of trans-species carcinogens and noncarcinogens.
Thirty chemicals or substances currently undergoing long-term carcinogenicity bioassays in rodents have been used in a project to further evaluate methods and information that may have the capability of predicting potential carcinogens. In our predictions the principal information used includes structural alerts and in vitro test results for Salmonella mutagenicity, relative subchronic toxicity...
متن کاملThe Problem of Pseudocarcinogenicity in Rodent Bioassays
Pseudocarcinogenicity is defined as the enhancement of tumor risk by a nongenotoxic mechanism in physiologically abnormal animals. In the case of rats, severe endocrine disturbance secondary to overfeeding is the commonest cause of physiological abnormality. Pseudoanticarcinogenicity is the counterpart of pseudocarcinogenicity. The literature abounds with, and is seriously confused by, examples...
متن کاملTarget organs in chronic bioassays of 533 chemical carcinogens.
A compendium of carcinogenesis bioassay results organized by target organ is presented for 533 chemicals that are carcinogenic in at least one species. This compendium is based primarily on experiments in rats or mice; results in hamsters, nonhuman primates, and dogs are also reported. The compendium can be used to identify chemicals that induce tumors at particular sites, and to determine whet...
متن کاملMonte Carlo simulation of rodent carcinogenicity bioassays.
In this paper we describe a simulation, by Monte Carlo methods, of the results of rodent carcinogenicity bioassays. Our aim is to study how the observed correlation between carcinogenic potency (beta or 1n2/TD50) and maximum tolerated dose (MTD) arises, and whether the existence of this correlation leads to an artificial correlation between carcinogenic potencies in rats and mice. The validity ...
متن کاملChemical carcinogenesis: too many rodent carcinogens.
The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion--about half--of all chemicals tested (whether natural or synthetic) are indeed rodent carcinog...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental and Molecular Mutagenesis
سال: 2002
ISSN: 0893-6692,1098-2280
DOI: 10.1002/em.10068